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Target
Thioredoxin
Ligand
BDBM50366237
Substrate
n/a
Meas. Tech.
ChEMBL_884454 (CHEMBL2212216)
Ki
3110±n/a nM
Citation
 Yang, J; Li, C; Ding, L; Guo, Q; You, Q; Jin, S Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain. J Nat Prod 75:1108-16 (2012) [PubMed]  Article 
Target
Name:
Thioredoxin
Synonyms:
ADF | ATL-derived factor | SASP | Surface-associated sulphydryl protein | THIO_HUMAN | TRDX | TRX | TRX1 | TXN
Type:
PROTEIN
Mol. Mass.:
11732.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_934906
Residue:
105
Sequence:
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
  
Inhibitor
Name:
BDBM50366237
Synonyms:
GAMBOGIC ACID
Type:
Small organic molecule
Emp. Form.:
C38H44O8
Mol. Mass.:
628.7512
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6][C@@]1([#6])[#8]-c2c(-[#6]\[#6]=[#6](\[#6])-[#6])c3-[#8][C@@]45[#6@H]6-[#6]-[#6@@H](-[#6]=[#6]4-[#6](=O)-c3c(-[#8])c2-[#6]=[#6]1)-[#6](=O)[C@]5([#6]\[#6]=[#6](\[#6])-[#6](-[#8])=O)[#8]C6([#6])[#6] |r,c:22,33,TLB:22:21:18:42.43,THB:33:32:18:42.43,43:19:23.22:34.32|
Structure:
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