Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM106608
Substrate
n/a
Meas. Tech.
ChEMBL_882013 (CHEMBL2213508)
EC50
40±n/a nM
Citation
 Galley, G; Stalder, H; Goergler, A; Hoener, MC; Norcross, RD Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012. Bioorg Med Chem Lett 22:5244-8 (2012) [PubMed]  Article 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TA1 | TAAR1 | TAAR1_HUMAN | TAR1 | TRAR1 | trace amine-associated receptor 1
Type:
PROTEIN
Mol. Mass.:
39107.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792734
Residue:
339
Sequence:
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
  
Inhibitor
Name:
BDBM106608
Synonyms:
CHEMBL2206388 | US8586617, 113
Type:
Small organic molecule
Emp. Form.:
C13H18N4O
Mol. Mass.:
246.3082
SMILES:
COc1cccc(n1)N(Cc1cnc[nH]1)C(C)C
Structure:
Search PDB for entries with ligand similarity: