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Target
Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM50402683
Substrate
n/a
Meas. Tech.
ChEMBL_886874 (CHEMBL2211372)
IC50
25±n/a nM
Citation
 Tichenor, MS; Keith, JM; Jones, WM; Pierce, JM; Merit, J; Hawryluk, N; Seierstad, M; Palmer, JA; Webb, M; Karbarz, MJ; Wilson, SJ; Wennerholm, ML; Woestenborghs, F; Beerens, D; Luo, L; Brown, SM; Boeck, MD; Chaplan, SR; Breitenbucher, JG Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites. Bioorg Med Chem Lett 22:7357-62 (2012) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
  
Inhibitor
Name:
BDBM50402683
Synonyms:
CHEMBL2207340
Type:
Small organic molecule
Emp. Form.:
C24H22ClN5O2S
Mol. Mass.:
479.982
SMILES:
Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nsnc34)c2)cc1
Structure:
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