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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50402680
Substrate
n/a
Meas. Tech.
ChEMBL_886873 (CHEMBL2211371)
IC50
6.7±n/a nM
Citation
 Tichenor, MS; Keith, JM; Jones, WM; Pierce, JM; Merit, J; Hawryluk, N; Seierstad, M; Palmer, JA; Webb, M; Karbarz, MJ; Wilson, SJ; Wennerholm, ML; Woestenborghs, F; Beerens, D; Luo, L; Brown, SM; Boeck, MD; Chaplan, SR; Breitenbucher, JG Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites. Bioorg Med Chem Lett 22:7357-62 (2012) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM50402680
Synonyms:
CHEMBL2207343
Type:
Small organic molecule
Emp. Form.:
C27H25ClN4O2
Mol. Mass.:
472.966
SMILES:
Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cncc4ccccc34)c2)cc1
Structure:
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