Reaction Details Report a problem with these data
Target
Malate dehydrogenase, cytoplasmic
Ligand
BDBM50404713
Substrate
n/a
Meas. Tech.
ChEMBL_52262 (CHEMBL665215)
IC50
912010.84±n/a nM
Citation
 Coats, EA; Shah, KJ; Milstein, SR; Genther, CS; Nene, DM; Roesener, J; Schmidt, J; Pleiss, M; Wagner, E; Baker, JK 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions. J Med Chem 25:57-63 (1982) [PubMed]  Article 
Target
Name:
Malate dehydrogenase, cytoplasmic
Synonyms:
Cytosolic malate dehydrogenase | MDH1 | MDHC_PIG | Malate Dehydrogenase, cytoplasmic | Malate dehydrogenase cytoplasmic
Type:
Oxidoreductase; homodimer
Mol. Mass.:
36453.77
Organism:
Sus scrofa (pig)
Description:
Porcine heart cytoplasmic fraction.
Residue:
334
Sequence:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQYPDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIVEGLPINDFSREKMDLTAKELAEEKETAFEFLSSA
  
Inhibitor
Name:
BDBM50404713
Synonyms:
CHEMBL141025
Type:
Small organic molecule
Emp. Form.:
C12H9NO4
Mol. Mass.:
231.2042
SMILES:
CC(=O)c1ccc2c(O)c(cnc2c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: