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Target
Dopamine beta-hydroxylase
Ligand
BDBM50014978
Substrate
n/a
Meas. Tech.
ChEBML_59425
IC50
74±n/a nM
Citation
 Burke, BJ; Hopfinger, AJ 1-(substituted-benzyl)imidazole-2(3H)-thione inhibitors of dopamine beta-hydroxylase. J Med Chem 33:274-81 (1990) [PubMed]  Article 
Target
Name:
Dopamine beta-hydroxylase
Synonyms:
DOPO_RAT | Dbh
Type:
PROTEIN
Mol. Mass.:
69869.10
Organism:
Rattus norvegicus
Description:
ChEMBL_59425
Residue:
620
Sequence:
MQPHLSHQPCWSLPSPSVREAASMYGTAVAIFLVILVAALQGSEPPESPFPYHIPLDPEGTLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYFADAWSDQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITELPLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNESEAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPLGSSGSSRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPNITSAVEEPDPRCPIRQTRGPAGPFVVITHGGRH
  
Inhibitor
Name:
BDBM50014978
Synonyms:
1-(3,5-Difluoro-4-hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione | CHEMBL433493
Type:
Small organic molecule
Emp. Form.:
C10H8F2N2OS
Mol. Mass.:
242.245
SMILES:
Oc1c(F)cc(Cn2cc[nH]c2=S)cc1F
Structure:
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