Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50040702
Substrate
n/a
Meas. Tech.
ChEMBL_38119 (CHEMBL650074)
IC50
71400000±n/a nM
Citation
 So, SS; Karplus, M Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem 39:5246-56 (1997) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50040702
Synonyms:
8-Chloro-5-(2-fluoro-phenyl)-7-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one | CHEMBL356411 | Ro-20-8552
Type:
Small organic molecule
Emp. Form.:
C16H12ClFN2O
Mol. Mass.:
302.731
SMILES:
Cc1cc2c(NC(=O)CN=C2c2ccccc2F)cc1Cl |c:9|
Structure:
Search PDB for entries with ligand similarity: