Reaction Details Report a problem with these data
Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50408760
Substrate
n/a
Meas. Tech.
ChEMBL_155111 (CHEMBL763685)
IC50
18000±n/a nM
Citation
 Vippagunta, SR; Dorn, A; Matile, H; Bhattacharjee, AK; Karle, JM; Ellis, WY; Ridley, RG; Vennerstrom, JL Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. J Med Chem 42:4630-9 (1999) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50408760
Synonyms:
CHEMBL139984
Type:
Small organic molecule
Emp. Form.:
C16H22ClN3
Mol. Mass.:
291.819
SMILES:
CCN(CC)CC(C)Nc1ccnc2cc(Cl)ccc12
Structure:
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