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Target
fMet-Leu-Phe receptor
Ligand
BDBM50418335
Substrate
n/a
Meas. Tech.
ChEMBL_788190 (CHEMBL1919337)
IC50
501±n/a nM
Citation
 Morley, AD; Cook, A; King, S; Roberts, B; Lever, S; Weaver, R; Macdonald, C; Unitt, J; Fagura, M; Phillips, T; Lewis, R; Wenlock, M Discovery of pyrazoles as novel FPR1 antagonists. Bioorg Med Chem Lett 21:6456-60 (2011) [PubMed]  Article 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM50418335
Synonyms:
CHEMBL1770297
Type:
Small organic molecule
Emp. Form.:
C23H25N3O3S
Mol. Mass.:
423.528
SMILES:
CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ccccc4[nH]3)c(C)c2c1
Structure:
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