Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50420855
Substrate
n/a
Meas. Tech.
ChEMBL_839817 (CHEMBL2089828)
EC50
78±n/a nM
Citation
 Scott, JS; Birch, AM; Brocklehurst, KJ; Broo, A; Brown, HS; Butlin, RJ; Clarke, DS; Davidsson, O; Ertan, A; Goldberg, K; Groombridge, SD; Hudson, JA; Laber, D; Leach, AG; Macfaul, PA; McKerrecher, D; Pickup, A; Schofield, P; Svensson, PH; Sörme, P; Teague, J Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation. J Med Chem 55:5361-79 (2012) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_MOUSE | Gpr119
Type:
PROTEIN
Mol. Mass.:
37009.07
Organism:
Mus musculus
Description:
ChEMBL_1506420
Residue:
335
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM50420855
Synonyms:
CHEMBL2086668
Type:
Small organic molecule
Emp. Form.:
C21H35N5O5S
Mol. Mass.:
469.598
SMILES:
C[C@@H]1CN(CCN1c1ncc(OCC2CCN(CC2)S(C)(=O)=O)cn1)C(=O)OC(C)(C)C |r|
Structure:
Search PDB for entries with ligand similarity: