Reaction Details Report a problem with these data
Target
Endothelin-1 receptor
Ligand
BDBM50422259
Substrate
n/a
Meas. Tech.
ChEMBL_65664 (CHEMBL677091)
IC50
5012±n/a nM
Citation
 Bradbury, RH; Bath, C; Butlin, RJ; Dennis, M; Heys, C; Hunt, SJ; James, R; Mortlock, AA; Sumner, NF; Tang, EK; Telford, B; Whiting, E; Wilson, C New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides. J Med Chem 40:996-1004 (1997) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50422259
Synonyms:
CHEMBL266684
Type:
Small organic molecule
Emp. Form.:
C17H16IN3O2S
Mol. Mass.:
453.297
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1ccc(I)cn1
Structure:
Search PDB for entries with ligand similarity: