Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50423785
Substrate
n/a
Meas. Tech.
ChEMBL_698608 (CHEMBL1647881)
Ki
2.5±n/a nM
Citation
 Munei, Y; Shimamoto, K; Harada, M; Yoshida, T; Chuman, H Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures (II). Bioorg Med Chem Lett 21:141-4 (2010) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA2 | CAH2_BOVIN | Carbonic anhydrase | Carbonic anhydrase 2 | Carbonic anhydrase II | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29115.93
Organism:
Bos taurus
Description:
n/a
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK
  
Inhibitor
Name:
BDBM50423785
Synonyms:
3,4-Dichloro-Benzenesulfonamide | 3,4-Dichlorobenzenesulfonamide | CHEMBL366729
Type:
Small organic molecule
Emp. Form.:
C6H5Cl2NO2S
Mol. Mass.:
226.08
SMILES:
NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: