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Target
Dynamin-2
Ligand
BDBM50423883
Substrate
n/a
Meas. Tech.
ChEMBL_934669 (CHEMBL2318139)
IC50
5400±n/a nM
Citation
 Gordon, CP; Venn-Brown, B; Robertson, MJ; Young, KA; Chau, N; Mariana, A; Whiting, A; Chircop, M; Robinson, PJ; McCluskey, A Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem 56:46-59 (2013) [PubMed]  Article 
Target
Name:
Dynamin-2
Synonyms:
DYN2_RAT | Dnm2 | Dyn2
Type:
PROTEIN
Mol. Mass.:
98236.76
Organism:
Rattus norvegicus
Description:
ChEMBL_1458574
Residue:
870
Sequence:
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGRKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQNTSSHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPVGATSSFSAPPIPSRPGPQNVFANNDPFSAPPQIPSRPARIPPGIPPGVPSRRAPAAPSRPTIIRPAEPSLLD
  
Inhibitor
Name:
BDBM50423883
Synonyms:
CHEMBL2312430
Type:
Small organic molecule
Emp. Form.:
C24H41N3
Mol. Mass.:
371.6024
SMILES:
CCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Structure:
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