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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50423906
Substrate
n/a
Meas. Tech.
ChEMBL_934960 (CHEMBL2320329)
EC50
2100±n/a nM
Citation
 Laghezza, A; Pochetti, G; Lavecchia, A; Fracchiolla, G; Faliti, S; Piemontese, L; Di Giovanni, C; Iacobazzi, V; Infantino, V; Montanari, R; Capelli, D; Tortorella, P; Loiodice, F New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression. J Med Chem 56:60-72 (2013) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50423906
Synonyms:
CHEMBL2312710
Type:
Small organic molecule
Emp. Form.:
C23H22O3
Mol. Mass.:
346.419
SMILES:
Cc1cc(OC(Cc2ccccc2)C(O)=O)cc(C)c1-c1ccccc1
Structure:
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