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Target
Acyl-CoA desaturase 1
Ligand
BDBM50304937
Substrate
n/a
Meas. Tech.
ChEMBL_934509 (CHEMBL2321456)
IC50
18±n/a nM
Citation
 Zhang, Z; Sun, S; Kodumuru, V; Hou, D; Liu, S; Chakka, N; Sviridov, S; Chowdhury, S; McLaren, DG; Ratkay, LG; Khakh, K; Cheng, X; Gschwend, HW; Kamboj, R; Fu, J; Winther, MD Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome. J Med Chem 56:568-83 (2013) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50304937
Synonyms:
CHEMBL591796 | N-phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H24F3N5O2
Mol. Mass.:
483.4856
SMILES:
FC(F)(F)c1ccccc1C(=O)N1CCN(CC1)c1ccc(nn1)C(=O)NCCc1ccccc1
Structure:
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