Reaction Details Report a problem with these data
Target
Pro-cathepsin H
Ligand
BDBM50425030
Substrate
n/a
Meas. Tech.
ChEMBL_936320 (CHEMBL2321252)
Ki
129000±n/a nM
Citation
 Sosic, I; Mirkovic, B; Arenz, K; Stefane, B; Kos, J; Gobec, S Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem 56:521-33 (2013) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM50425030
Synonyms:
CHEMBL2312216
Type:
Small organic molecule
Emp. Form.:
C12H10N4O3
Mol. Mass.:
258.2328
SMILES:
Oc1c(CNCC#N)cc([N+]([O-])=O)c2cccnc12
Structure:
Search PDB for entries with ligand similarity: