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Target
Threonine--tRNA ligase 1, cytoplasmic
Ligand
BDBM50426197
Substrate
n/a
Meas. Tech.
ChEMBL_935846 (CHEMBL2317882)
Ki
399±n/a nM
Citation
 Teng, M; Hilgers, MT; Cunningham, ML; Borchardt, A; Locke, JB; Abraham, S; Haley, G; Kwan, BP; Hall, C; Hough, GW; Shaw, KJ; Finn, J Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem 56:1748-60 (2013) [PubMed]  Article 
Target
Name:
Threonine--tRNA ligase 1, cytoplasmic
Synonyms:
SYTC_HUMAN | TARS | TARS1 | Threonyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
83435.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_935846
Residue:
723
Sequence:
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEMYNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF
  
Inhibitor
Name:
BDBM50426197
Synonyms:
CHEMBL2316963
Type:
Small organic molecule
Emp. Form.:
C18H19ClN6O2
Mol. Mass.:
386.835
SMILES:
C[C@@H](O)[C@H](N)C(=O)NNc1cccc(c1)-c1ccc2c(N)nc(Cl)nc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: