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Target
Insulin-degrading enzyme
Ligand
BDBM50427715
Substrate
n/a
Meas. Tech.
ChEMBL_941899 (CHEMBL2329965)
Ki
78±n/a nM
Citation
 Abdul-Hay, SO; Lane, AL; Caulfield, TR; Claussin, C; Bertrand, J; Masson, A; Choudhry, S; Fauq, AH; Maharvi, GM; Leissring, MA Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. J Med Chem 56:2246-55 (2013) [PubMed]  Article 
Target
Name:
Insulin-degrading enzyme
Synonyms:
Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
117968.59
Organism:
Homo sapiens (Human)
Description:
P14735
Residue:
1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
  
Inhibitor
Name:
BDBM50427715
Synonyms:
CHEMBL2324219
Type:
Small organic molecule
Emp. Form.:
C38H46N8O8
Mol. Mass.:
742.8206
SMILES:
CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)[C@H](CC(=O)NO)Cc1ccc2ccccc2c1 |r,wU:4.3,27.28,37.38,wD:13.12,(33.53,-12.27,;33.55,-13.81,;32.23,-14.6,;34.89,-14.56,;36.21,-13.77,;36.19,-12.23,;37.52,-11.44,;37.5,-9.9,;36.15,-9.14,;38.82,-9.11,;37.56,-14.53,;37.58,-16.07,;38.88,-13.74,;40.23,-14.49,;40.25,-16.03,;41.5,-16.94,;42.97,-16.48,;43.86,-17.74,;42.94,-18.98,;43.25,-20.49,;42.1,-21.52,;40.64,-21.02,;40.32,-19.52,;41.48,-18.49,;41.56,-13.7,;41.54,-12.16,;42.9,-14.45,;44.23,-13.67,;44.21,-12.12,;45.53,-11.33,;45.52,-9.79,;44.17,-9.03,;42.85,-9.82,;42.88,-11.37,;41.5,-9.08,;45.57,-14.42,;45.6,-15.96,;46.89,-13.63,;48.24,-14.37,;48.26,-15.91,;46.94,-16.7,;49.6,-16.66,;49.63,-18.2,;46.87,-12.09,;48.19,-11.3,;49.53,-12.05,;50.84,-11.27,;50.82,-9.72,;52.13,-8.93,;52.1,-7.39,;50.74,-6.65,;49.44,-7.45,;49.47,-8.98,;48.16,-9.77,)|
Structure:
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