Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit rho-1
Ligand
BDBM50428276
Substrate
n/a
Meas. Tech.
ChEMBL_946446 (CHEMBL2339626)
IC50
58610±n/a nM
Citation
 Gavande, N; Kim, HL; Doddareddy, MR; Johnston, GA; Chebib, M; Hanrahan, JR Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of?1 GABAC Receptors. ACS Med Chem Lett 4:402-7 (2013) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-1
Synonyms:
GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55892.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456653
Residue:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
  
Inhibitor
Name:
BDBM50428276
Synonyms:
CHEMBL2337487
Type:
Small organic molecule
Emp. Form.:
C31H46BF2N4O4P
Mol. Mass.:
618.503
SMILES:
CCCCP(O)(=O)C1=C[C@H](CC1)NC(=O)CCCCCNC(=O)CCC1=C2C(C)=CC(C)=[N+]2[B-](F)(F)n2c(C)cc(C)c12 |r,c:26,29,32,t:7|
Structure:
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