Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50430383
Substrate
n/a
Meas. Tech.
ChEMBL_943827 (CHEMBL2346276)
Ki
290±n/a nM
Citation
 Zhang, X; Glunz, PW; Jiang, W; Schmitt, A; Newman, M; Barbera, FA; Bozarth, JM; Rendina, AR; Wei, A; Wen, X; Rossi, KA; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR; Scott Priestley, E Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors. Bioorg Med Chem Lett 23:1604-7 (2013) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50430383
Synonyms:
CHEMBL2334315
Type:
Small organic molecule
Emp. Form.:
C24H31ClN6O4
Mol. Mass.:
502.994
SMILES:
CC(C)(C)OC(=O)CNc1nc(Cl)c2n([C@@H](CC2(C)C)C(=O)NCc2ccc(cc2)C(N)=N)c1=O |r|
Structure:
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