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Target
Prothrombin
Ligand
BDBM50430382
Substrate
n/a
Meas. Tech.
ChEMBL_943828 (CHEMBL2346277)
Ki
150±n/a nM
Citation
 Zhang, X; Glunz, PW; Jiang, W; Schmitt, A; Newman, M; Barbera, FA; Bozarth, JM; Rendina, AR; Wei, A; Wen, X; Rossi, KA; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR; Scott Priestley, E Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors. Bioorg Med Chem Lett 23:1604-7 (2013) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50430382
Synonyms:
CHEMBL2334317
Type:
Small organic molecule
Emp. Form.:
C19H24N6O2
Mol. Mass.:
368.4329
SMILES:
CCCNc1cnc2CC[C@@H](C(=O)NCc3ccc(cc3)C(N)=N)n2c1=O |r|
Structure:
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