Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50431086
Substrate
n/a
Meas. Tech.
ChEMBL_947855 (CHEMBL2343131)
IC50
2.5±n/a nM
Citation
 Hondo, T; Warizaya, M; Niimi, T; Namatame, I; Yamaguchi, T; Nakanishi, K; Hamajima, T; Harada, K; Sakashita, H; Matsumoto, Y; Orita, M; Takeuchi, M 4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors. J Med Chem 56:3582-92 (2013) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
DAAO | DAMOX | Dao | Dao1 | OXDA_MOUSE
Type:
PROTEIN
Mol. Mass.:
38667.41
Organism:
Mus musculus
Description:
ChEMBL_947855
Residue:
345
Sequence:
MRVAVIGAGVIGLSTALCIHERYHPTQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWSQQTFDYLLSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKNAVLGFRKLTPSEMDLFPDYGYGWFNTSLLLEGKSYLPWLTERLTERGVKLIHRKVESLEEVARGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGIFQLGNWSGLNSVRDHNTIWKSCCKLEPTLKNARIVGELTGFRPVRPQVRLEREWLRHGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKKLSRLPPSHL
  
Inhibitor
Name:
BDBM50431086
Synonyms:
CHEMBL2338800 | US10202399, Example 212 | US10463663, Example 2 | US11129828, Example 2 | US9212147, 212 | US9290456, 2 | US9931340, Example 2
Type:
Small organic molecule
Emp. Form.:
C12H11FN2O2
Mol. Mass.:
234.2263
SMILES:
Oc1cc(CCc2ccc(F)cc2)n[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: