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Target
Prostaglandin E synthase
Ligand
BDBM50431404
Substrate
n/a
Meas. Tech.
ChEMBL_952397 (CHEMBL2352763)
IC50
>10000±n/a nM
Citation
 Shiro, T; Kakiguchi, K; Takahashi, H; Nagata, H; Tobe, M Synthesis and biological evaluation of substituted imidazoquinoline derivatives as mPGES-1 inhibitors. Bioorg Med Chem 21:2068-78 (2013) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50431404
Synonyms:
CHEMBL2348047
Type:
Small organic molecule
Emp. Form.:
C23H15BrClN3O
Mol. Mass.:
464.742
SMILES:
Clc1ccccc1-c1nc2c(n1Cc1ccccc1)c(=O)[nH]c1cc(Br)ccc21
Structure:
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