Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM50433370
Substrate
n/a
Meas. Tech.
ChEMBL_956786 (CHEMBL2379311)
IC50
61±n/a nM
Citation
 Khan, I; Ibrar, A; Abbas, N Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds. Eur J Med Chem 63:854-68 (2013) [PubMed]  Article 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN
Type:
Protein
Mol. Mass.:
57094.82
Organism:
Bos taurus (Cattle)
Description:
P19111
Residue:
533
Sequence:
MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLGDGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLCGVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDASVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQDHTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKANELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYALGGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHIMAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
  
Inhibitor
Name:
BDBM50433370
Synonyms:
CHEMBL2375482
Type:
Small organic molecule
Emp. Form.:
C13H7BrN4OS
Mol. Mass.:
347.19
SMILES:
Brc1ccc(cc1)-c1nnc2sc(nn12)-c1ccoc1
Structure:
Search PDB for entries with ligand similarity: