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Target
Dual specificity protein kinase CLK4
Ligand
BDBM50435489
Substrate
n/a
Meas. Tech.
ChEMBL_965912 (CHEMBL2394343)
IC50
60±n/a nM
Citation
 Coombs, TC; Tanega, C; Shen, M; Wang, JL; Auld, DS; Gerritz, SW; Schoenen, FJ; Thomas, CJ; Aubé, J Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett 23:3654-61 (2013) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK4
Synonyms:
CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57522.53
Organism:
Homo sapiens (Human)
Description:
gi_10190706
Residue:
481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
  
Inhibitor
Name:
BDBM50435489
Synonyms:
CHEMBL1902528
Type:
Small organic molecule
Emp. Form.:
C17H14N6
Mol. Mass.:
302.3333
SMILES:
C(Nc1nccc(n1)-c1ccc2[nH]ncc2c1)c1cccnc1
Structure:
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