Reaction Details Report a problem with these data
Target
Caspase-7
Ligand
BDBM50435965
Substrate
n/a
Meas. Tech.
ChEMBL_964096 (CHEMBL2394449)
IC50
>500000±n/a nM
Citation
 Limpachayaporn, P; Riemann, B; Kopka, K; Schober, O; Schäfers, M; Haufe, G Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem 64:562-78 (2013) [PubMed]  Article 
Target
Name:
Caspase-7
Synonyms:
Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Homo sapiens (Human)
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM50435965
Synonyms:
CHEMBL2391979
Type:
Small organic molecule
Emp. Form.:
C16H20N2O6S
Mol. Mass.:
368.405
SMILES:
COC[C@@H]1CC[C@@H](COC)N1S(=O)(=O)c1ccc2NC(=O)C(=O)c2c1 |r|
Structure:
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