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Target
Tyrosine-protein kinase ZAP-70
Ligand
BDBM50436850
Substrate
n/a
Meas. Tech.
ChEMBL_971444 (CHEMBL2406322)
IC50
9700±n/a nM
Citation
 Marsilje, TH; Pei, W; Chen, B; Lu, W; Uno, T; Jin, Y; Jiang, T; Kim, S; Li, N; Warmuth, M; Sarkisova, Y; Sun, F; Steffy, A; Pferdekamper, AC; Li, AG; Joseph, SB; Kim, Y; Liu, B; Tuntland, T; Cui, X; Gray, NS; Steensma, R; Wan, Y; Jiang, J; Chopiuk, G; Li, J; Gordon, WP; Richmond, W; Johnson, K; Chang, J; Groessl, T; He, YQ; Phimister, A; Aycinena, A; Lee, CC; Bursulaya, B; Karanewsky, DS; Seidel, HM; Harris, JL; Michellys, PY Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase  J Med Chem 56:5675-90 (2014) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ZAP-70
Synonyms:
70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa
Type:
Enzyme
Mol. Mass.:
69881.61
Organism:
Homo sapiens (Human)
Description:
ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column.
Residue:
619
Sequence:
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA
  
Inhibitor
Name:
BDBM50436850
Synonyms:
CERITINIB | CHEMBL2403108 | LDK378 | US10053458, Comparative Example 2 | US10618884, Example 16 | US9809572, Example 16
Type:
Small organic molecule
Emp. Form.:
C28H36ClN5O3S
Mol. Mass.:
558.135
SMILES:
CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
Structure:
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