Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Ligand
BDBM50437711
Substrate
n/a
Meas. Tech.
ChEMBL_974637 (CHEMBL2410563)
IC50
1500±n/a nM
Citation
 Moore, JD; Potter, A Pin1 inhibitors: Pitfalls, progress and cellular pharmacology. Bioorg Med Chem Lett 23:4283-91 (2013) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Synonyms:
PIN4 | PIN4_HUMAN | PPIase Pin4 | Par14 | Parvulin 14 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 2 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 | Peptidyl-prolyl cis/trans isomerase EPVH | Rotamase Pin4 | hPar14
Type:
PROTEIN
Mol. Mass.:
13820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502606
Residue:
131
Sequence:
MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK
  
Inhibitor
Name:
BDBM50437711
Synonyms:
CHEMBL2409076
Type:
Small organic molecule
Emp. Form.:
C22H18N2O8
Mol. Mass.:
438.3869
SMILES:
CCOC(=O)Cn1c(=O)c2ccc3c4c(ccc(c24)c1=O)c(=O)n(CC(=O)OCC)c3=O
Structure:
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