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Target
Cathepsin D
Ligand
BDBM50438358
Substrate
n/a
Meas. Tech.
ChEMBL_973546 (CHEMBL2410948)
IC50
8.0±n/a nM
Citation
 Ng, RA; Sun, M; Bowers, S; Hom, RK; Probst, GD; John, V; Fang, LY; Maillard, M; Gailunas, A; Brogley, L; Neitz, RJ; Tung, JS; Pleiss, MA; Konradi, AW; Sham, HL; Dappen, MS; Adler, M; Yao, N; Zmolek, W; Nakamura, D; Quinn, KP; Sauer, JM; Bova, MP; Ruslim, L; Artis, DR; Yednock, TA Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. Bioorg Med Chem Lett 23:4674-9 (2013) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50438358
Synonyms:
CHEMBL2408757
Type:
Small organic molecule
Emp. Form.:
C28H35F2N3O3
Mol. Mass.:
499.5926
SMILES:
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@H]1CC(C)(C)Oc2ccc(CC(C)(C)C#N)cc12 |r|
Structure:
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