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Target
Casein kinase I isoform delta
Ligand
BDBM50439433
Substrate
n/a
Meas. Tech.
ChEMBL_977607 (CHEMBL2423574)
IC50
13±n/a nM
Citation
 Mente, S; Arnold, E; Butler, T; Chakrapani, S; Chandrasekaran, R; Cherry, K; DiRico, K; Doran, A; Fisher, K; Galatsis, P; Green, M; Hayward, M; Humphrey, J; Knafels, J; Li, J; Liu, S; Marconi, M; McDonald, S; Ohren, J; Paradis, V; Sneed, B; Walton, K; Wager, T Ligand-protein interactions of selective casein kinase 1d inhibitors. J Med Chem 56:6819-28 (2013) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50439433
Synonyms:
CHEMBL2420702
Type:
Small organic molecule
Emp. Form.:
C17H17FN4
Mol. Mass.:
296.3421
SMILES:
CNCc1cc(ccn1)-c1cn(C)nc1-c1ccc(F)cc1
Structure:
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