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Target
Histone deacetylase 3
Ligand
BDBM50440911
Substrate
n/a
Meas. Tech.
ChEMBL_984988 (CHEMBL2433162)
IC50
>50000±n/a nM
Citation
 Blackburn, C; Barrett, C; Chin, J; Garcia, K; Gigstad, K; Gould, A; Gutierrez, J; Harrison, S; Hoar, K; Lynch, C; Rowland, RS; Tsu, C; Ringeling, J; Xu, H Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J Med Chem 56:7201-11 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50440911
Synonyms:
CHEMBL2431902
Type:
Small organic molecule
Emp. Form.:
C15H20N2O3
Mol. Mass.:
276.3309
SMILES:
CC(C)(C)C(=O)N1CCc2cc(ccc2C1)C(=O)NO
Structure:
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