Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 15
Ligand
BDBM50441090
Substrate
n/a
Meas. Tech.
ChEMBL_986148 (CHEMBL2432948)
IC50
400±n/a nM
Citation
 Huart, AS; Saxty, B; Merritt, A; Nekulova, M; Lewis, S; Huang, Y; Vojtesek, B; Kettleborough, C; Hupp, TR A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway. Bioorg Med Chem Lett 23:5578-85 (2013) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 15
Synonyms:
ERK-8 | ERK7 | ERK8 | Extracellular signal-regulated kinase 8 | MAPK15 | MK15_HUMAN | Mitogen-activated protein kinase 15
Type:
Serine/threonine-protein kinase
Mol. Mass.:
59850.14
Organism:
Homo sapiens (Human)
Description:
gi_95147356
Residue:
544
Sequence:
MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV
  
Inhibitor
Name:
BDBM50441090
Synonyms:
CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C15H14N4O
Mol. Mass.:
266.2979
SMILES:
CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Structure:
Search PDB for entries with ligand similarity: