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Target
Delta-aminolevulinic acid dehydratase
Ligand
BDBM50441100
Substrate
n/a
Meas. Tech.
ChEMBL_983894 (CHEMBL2433504)
IC50
>1000000±n/a nM
Citation
 Lentz, CS; Stumpfe, D; Bajorath, J; Famulok, M; Hoerauf, A; Pfarr, KM New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria. Bioorg Med Chem Lett 23:5558-62 (2013) [PubMed]  Article 
Target
Name:
Delta-aminolevulinic acid dehydratase
Synonyms:
ALAD | ALADH | HEM2_HUMAN | Porphobilinogen synthase
Type:
PROTEIN
Mol. Mass.:
36296.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1365623
Residue:
330
Sequence:
MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE
  
Inhibitor
Name:
BDBM50441100
Synonyms:
CHEMBL2430572
Type:
Small organic molecule
Emp. Form.:
C21H22FN3O3
Mol. Mass.:
383.4161
SMILES:
OC(=O)c1ccc2n(Cc3ccc(F)cc3)c(=O)n(CCN3CCCC3)c2c1
Structure:
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