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Target
Inward rectifier potassium channel 2
Ligand
BDBM50442600
Substrate
n/a
Meas. Tech.
ChEMBL_990654 (CHEMBL2443476)
IC50
>50000±n/a nM
Citation
 Tang, H; de Jesus, RK; Walsh, SP; Zhu, Y; Yan, Y; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Roy, S; Kaczorowski, GJ; Yang, L; Garcia, ML; Pasternak, A Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one. Bioorg Med Chem Lett 23:5829-32 (2013) [PubMed]  Article 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1
Type:
PROTEIN
Mol. Mass.:
48281.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515520
Residue:
427
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM50442600
Synonyms:
CHEMBL2441437 | US9056859, 1
Type:
Small organic molecule
Emp. Form.:
C23H24N6O3
Mol. Mass.:
432.4751
SMILES:
O=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3c2)CC1
Structure:
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