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Target
Solute carrier family 2, facilitated glucose transporter member 1
Ligand
BDBM50428447
Substrate
n/a
Meas. Tech.
ChEMBL_1279734 (CHEMBL3095124)
IC50
10600±n/a nM
Citation
 Tuccinardi, T; Granchi, C; Iegre, J; Paterni, I; Bertini, S; Macchia, M; Martinelli, A; Qian, Y; Chen, X; Minutolo, F Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells. Bioorg Med Chem Lett 23:6923-7 (2013) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 1
Synonyms:
GLUT-1 | GLUT1 | GTR1_HUMAN | Glucose Transporter 1 (hGLUT1) | Glucose transporter | Glucose transporter type 1, erythrocyte/brain | HepG2 glucose transporter | SLC2A1
Type:
Protein
Mol. Mass.:
54091.71
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
492
Sequence:
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
  
Inhibitor
Name:
BDBM50428447
Synonyms:
CHEMBL479638
Type:
Small organic molecule
Emp. Form.:
C14H12ClNO3
Mol. Mass.:
277.703
SMILES:
CC(N=O)c1ccc(-c2ccc(O)cc2)c(Cl)c1O
Structure:
Search PDB for entries with ligand similarity: