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Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50236238
Substrate
n/a
Meas. Tech.
ChEMBL_1281399 (CHEMBL3101628)
EC50
730±n/a nM
Citation
 Macchiarulo, A; Gioiello, A; Thomas, C; Pols, TW; Nuti, R; Ferrari, C; Giacchè, N; De Franco, F; Pruzanski, M; Auwerx, J; Schoonjans, K; Pellicciari, R Probing the Binding Site of Bile Acids in TGR5. ACS Med Chem Lett 4:1158-62 (2013) [PubMed]  Article 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM50236238
Synonyms:
(3alpha,5beta)-3-hydroxycholan-24-oic acid | 3alpha-hydroxy-5beta-cholan-24-oic acid | 3alpha-hydroxy-5beta-cholanic acid | 3alpha-hydroxy-5beta-cholanoic acid | 5beta-cholanic acid-3alpha-ol | CHEMBL1478 | LCA | cid_9903 | lithocholic acid
Type:
Small organic molecule
Emp. Form.:
C24H40O3
Mol. Mass.:
376.5726
SMILES:
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r|
Structure:
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