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Target
Urotensin-2 receptor
Ligand
BDBM50445368
Substrate
n/a
Meas. Tech.
ChEMBL_1285482 (CHEMBL3108414)
EC50
>0.000±n/a nM
Comments
>0.000001 20220121
Citation
 Chatenet, D; Folch, B; Feytens, D; Létourneau, M; Tourwé, D; Doucet, N; Fournier, A Development and pharmacological characterization of conformationally constrained urotensin II-related peptide agonists. J Med Chem 56:9612-22 (2014) [PubMed]  Article 
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42725.34
Organism:
RAT
Description:
Urotensin-II UTS2R RAT::P49684
Residue:
386
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
  
Inhibitor
Name:
BDBM50445368
Synonyms:
CHEMBL3104466
Type:
Small organic molecule
Emp. Form.:
C48H63N9O10S2
Mol. Mass.:
990.198
SMILES:
CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2Cc3ccccc3C[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O |r|
Structure:
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