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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50445484
Substrate
n/a
Meas. Tech.
ChEMBL_1284646 (CHEMBL3107227)
EC50
33±n/a nM
Citation
 Yu, M; Ken Zhang, J; Wang, Y; Zhu, J; Kayser, F; Medina, JC; Siegler, K; Conn, M; Shan, B; Grillo, MP; Coward, P; Jim Liu, J Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists. Bioorg Med Chem Lett 24:156-60 (2013) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50445484
Synonyms:
CHEMBL3104880
Type:
Small organic molecule
Emp. Form.:
C23H19Cl2N3O5S
Mol. Mass.:
520.385
SMILES:
CC(C)N1C(=O)c2cc(C)nc(Oc3cc(NS(=O)(=O)c4ccc(Cl)cc4)ccc3Cl)c2C1=O
Structure:
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