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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50446146
Substrate
n/a
Meas. Tech.
ChEMBL_1287960 (CHEMBL3110531)
Ki
10000±n/a nM
Citation
 Haftchenary, S; Luchman, HA; Jouk, AO; Veloso, AJ; Page, BD; Cheng, XR; Dawson, SS; Grinshtein, N; Shahani, VM; Kerman, K; Kaplan, DR; Griffin, C; Aman, AM; Al-Awar, R; Weiss, S; Gunning, PT Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. ACS Med Chem Lett 4:1102-7 (2013) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50446146
Synonyms:
CHEMBL3108909
Type:
Small organic molecule
Emp. Form.:
C29H27F5N2O5S
Mol. Mass.:
610.592
SMILES:
CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(cc1)C(O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Structure:
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