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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50446302
Substrate
n/a
Meas. Tech.
ChEMBL_1288038 (CHEMBL3110541)
EC50
20±n/a nM
Citation
 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y Discovery of Tertiary Amine and Indole Derivatives as Potent ROR?t Inverse Agonists. ACS Med Chem Lett 5:65-8 (2014) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50446302
Synonyms:
CHEMBL3109325
Type:
Small organic molecule
Emp. Form.:
C27H32N2O3S
Mol. Mass.:
464.62
SMILES:
CCCN(Cc1ccccc1)Cc1ccc(NC(=O)Cc2ccc(cc2)S(=O)(=O)CC)cc1
Structure:
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