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Target
Plasmepsin II
Ligand
BDBM50446323
Substrate
n/a
Meas. Tech.
ChEMBL_1286909 (CHEMBL3110823)
IC50
12±n/a nM
Citation
 Meyers, MJ; Tortorella, MD; Xu, J; Qin, L; He, Z; Lang, X; Zeng, W; Xu, W; Qin, L; Prinsen, MJ; Sverdrup, FM; Eickhoff, CS; Griggs, DW; Oliva, J; Ruminski, PG; Jacobsen, EJ; Campbell, MA; Wood, DC; Goldberg, DE; Liu, X; Lu, Y; Lu, X; Tu, Z; Lu, X; Ding, K; Chen, X Evaluation of aminohydantoins as a novel class of antimalarial agents. ACS Med Chem Lett 5:89-93 (2014) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50446323
Synonyms:
CHEMBL588662
Type:
Small organic molecule
Emp. Form.:
C25H25N3O
Mol. Mass.:
383.4855
SMILES:
CCC(CN1C(=N)NC(C1=O)(c1ccccc1)c1ccccc1)c1ccccc1
Structure:
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