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Target
Histone-lysine N-methyltransferase Su(var)3-9
Ligand
BDBM50315537
Substrate
n/a
Meas. Tech.
ChEMBL_1294298 (CHEMBL3128975)
IC50
600±n/a nM
Citation
 Cherblanc, FL; Chapman, KL; Reid, J; Borg, AJ; Sundriyal, S; Alcazar-Fuoli, L; Bignell, E; Demetriades, M; Schofield, CJ; DiMaggio, PA; Brown, R; Fuchter, MJ On the histone lysine methyltransferase activity of fungal metabolite chaetocin. J Med Chem 56:8616-25 (2013) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase Su(var)3-9
Synonyms:
H3-K9-HMTase | Histone H3-K9 methyltransferase | KMT1 | Lysine N-methyltransferase 1 | Protein suppressor of variegation 3-9 | SUV39_DROME | Su(var)3-9
Type:
PROTEIN
Mol. Mass.:
71919.98
Organism:
Drosophila melanogaster
Description:
ChEMBL_1294298
Residue:
635
Sequence:
MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYETYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGRDNCRKVLF
  
Inhibitor
Name:
BDBM50315537
Synonyms:
CHEMBL1089316 | chaetocin
Type:
Small organic molecule
Emp. Form.:
C30H28N6O6S4
Mol. Mass.:
696.84
SMILES:
CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21 |r,THB:36:35:31.33:26.27,7:15:1.2:22.21,38:37:31.33:26.27,17:16:1.2:22.21|
Structure:
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