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Target
Streptokinase
Ligand
BDBM50449287
Substrate
n/a
Meas. Tech.
ChEMBL_1295409 (CHEMBL3131046)
IC50
3800±n/a nM
Citation
 Yestrepsky, BD; Kretz, CA; Xu, Y; Holmes, A; Sun, H; Ginsburg, D; Larsen, SD Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents. Bioorg Med Chem Lett 24:1538-44 (2014) [PubMed]  Article 
Target
Name:
Streptokinase
Synonyms:
STRQ_STRPY | ska
Type:
PROTEIN
Mol. Mass.:
49905.98
Organism:
Streptococcus pyogenes
Description:
ChEMBL_1295409
Residue:
440
Sequence:
MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLGRPSVNNSQLVVSVAGTVEGTNQEISLKFFEIDLTSRPAQGGKTEQGLRPKSKPLATDKGAMSHKLEKADLLKAIQEQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYRPKAVHNSAERVNVNYEVSFVSETGNLDFTPSLKEQYHLTTLAVGDSLSSQELAAIAQFILSKKHPDYIITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIEEKTNNTDLISEKYYILKKGEKPYDPFDRSHLKLFTIKYVDVDTKALLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMGYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEEREVYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM50449287
Synonyms:
CHEMBL3125353
Type:
Small organic molecule
Emp. Form.:
C29H28N2O3S
Mol. Mass.:
484.609
SMILES:
CC1(C)Cc2cc(ccc2-c2nc(SCCOCC#C)n(CC=C)c(=O)c12)C(=O)c1ccccc1
Structure:
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