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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50449354
Substrate
n/a
Meas. Tech.
ChEMBL_1297179 (CHEMBL3131368)
IC50
150±n/a nM
Citation
 Petros, AM; Swann, SL; Song, D; Swinger, K; Park, C; Zhang, H; Wendt, MD; Kunzer, AR; Souers, AJ; Sun, C Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein. Bioorg Med Chem Lett 24:1484-8 (2014) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50449354
Synonyms:
CHEMBL3126307
Type:
Small organic molecule
Emp. Form.:
C29H29N3O5S
Mol. Mass.:
531.623
SMILES:
CC(C)CNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1C(O)=O)-c1ccc(C)c2ccccc12
Structure:
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