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Target
Dihydrofolate reductase
Ligand
BDBM50000045
Substrate
n/a
Meas. Tech.
ChEMBL_1333437 (CHEMBL3231540)
IC50
57000±n/a nM
Citation
 Lin, SC; Holmes, GP; Dunn, DL; Skinner, CG Synthesis and biological activity of 8-oxadihydropteridines. J Med Chem 22:741-3 (1979) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50000045
Synonyms:
CHEMBL3228459
Type:
Small organic molecule
Emp. Form.:
C12H10N4O2
Mol. Mass.:
242.2334
SMILES:
Nc1nc(O)c2N=C(COc2n1)c1ccccc1 |c:6|
Structure:
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