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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50012595
Substrate
n/a
Meas. Tech.
ChEMBL_1351457 (CHEMBL3267322)
IC50
8.0±n/a nM
Citation
 Vaupel, A; Bold, G; De Pover, A; Stachyra-Valat, T; Hergovich-Lisztwan, J; Kallen, J; Masuya, K; Furet, P Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett 24:2110-4 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50012595
Synonyms:
CHEMBL3260812
Type:
Small organic molecule
Emp. Form.:
C24H18Cl2N2O2
Mol. Mass.:
437.318
SMILES:
Cc1cccc(c1)-c1nc(C(O)=O)c(-c2cccc(Cl)c2)n1-c1cc(Cl)ccc1C |(65.23,-4.64,;64.05,-5.63,;64.32,-7.16,;63.14,-8.15,;61.7,-7.62,;61.43,-6.1,;62.61,-5.11,;59.99,-5.57,;59.57,-4.09,;58.02,-4.03,;57.16,-2.75,;57.83,-1.37,;55.62,-2.86,;57.5,-5.48,;55.96,-5.47,;55.19,-6.8,;53.66,-6.8,;52.88,-5.46,;53.66,-4.12,;52.9,-2.79,;55.2,-4.13,;58.71,-6.43,;58.66,-7.96,;59.96,-8.77,;59.91,-10.31,;61.22,-11.12,;58.54,-11.04,;57.24,-10.22,;57.29,-8.68,;55.99,-7.86,)|
Structure:
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