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Target
Prostaglandin E synthase
Ligand
BDBM50017963
Substrate
n/a
Meas. Tech.
ChEMBL_1365207 (CHEMBL3292957)
IC50
>30000±n/a nM
Citation
 Lauro, G; Strocchia, M; Terracciano, S; Bruno, I; Fischer, K; Pergola, C; Werz, O; Riccio, R; Bifulco, G Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1). Eur J Med Chem 80:407-15 (2014) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50017963
Synonyms:
CHEMBL3289348
Type:
Small organic molecule
Emp. Form.:
C26H21F3N2O5S
Mol. Mass.:
530.516
SMILES:
CCOC(=O)C1=C(C(NC(=S)N1)c1ccc(o1)-c1cccc(c1)C(F)(F)F)C(=O)c1ccc(OC)cc1 |t:5|
Structure:
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