Reaction Details
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Cytochrome P450 3A4
Ligand
BDBM50020411
Substrate
n/a
Meas. Tech.
ChEMBL_1366633 (CHEMBL3296727)
IC50
20300±n/a nM
Citation
Hameed P, S; Chinnapattu, M; Shanbag, G; Manjrekar, P; Koushik, K; Raichurkar, A; Patil, V; Jatheendranath, S; Rudrapatna, SS; Barde, SP; Rautela, N; Awasthy, D; Morayya, S; Narayan, C; Kavanagh, S; Saralaya, R; Bharath, S; Viswanath, P; Mukherjee, K; Bandodkar, B; Srivastava, A; Panduga, V; Reddy, J; Prabhakar, KR; Sinha, A; Jiménez-Díaz, MB; Martínez, MS; Angulo-Barturen, I; Ferrer, S; Sanz, LM; Gamo, FJ; Duffy, S; Avery, VM; Magistrado, PA; Lukens, AK; Wirth, DF; Waterson, D; Balasubramanian, V; Iyer, PS; Narayanan, S; Hosagrahara, V; Sambandamurthy, VK; Ramachandran, S Aminoazabenzimidazoles, a novel class of orally active antimalarial agents. J Med Chem 57:5702-13 (2014) [PubMed] Article More Info.:
Target
Name:
Cytochrome P450 3A4
Synonyms:
Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase
Type:
Enzyme
Mol. Mass.:
57349.57
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
503
Sequence:
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA
Inhibitor
Name:
BDBM50020411
Synonyms:
CHEMBL3289813
Type:
Small organic molecule
Emp. Form.:
C18H15ClF6N4O2
Mol. Mass.:
468.781
SMILES:
CC(Oc1ccc2nc(N)n(CC(O)c3ccc(cc3Cl)C(F)(F)F)c2n1)C(F)(F)F
Structure:
