Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50021054
Substrate
n/a
Meas. Tech.
ChEMBL_1365856 (CHEMBL3296477)
Ki
239±n/a nM
Citation
 Denora, N; Margiotta, N; Laquintana, V; Lopedota, A; Cutrignelli, A; Losacco, M; Franco, M; Natile, G Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand. ACS Med Chem Lett 5:685-9 (2014) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50021054
Synonyms:
CHEMBL3287610
Type:
Small organic molecule
Emp. Form.:
C35H38ClN7O2
Mol. Mass.:
624.175
SMILES:
CCCN(CCC)C(=O)Cc1c(nc2c(NC(=O)CN(Cc3ccccn3)Cc3ccccn3)cccn12)-c1ccc(Cl)cc1
Structure:
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