Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 1
Ligand
BDBM50024254
Substrate
n/a
Meas. Tech.
ChEMBL_1435254 (CHEMBL3390700)
IC50
>10000±n/a nM
Citation
 Wen, W; Young, SE; Duvernay, MT; Schulte, ML; Nance, KD; Melancon, BJ; Engers, J; Locuson, CW; Wood, MR; Daniels, JS; Wu, W; Lindsley, CW; Hamm, HE; Stauffer, SR Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett 24:4708-13 (2014) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50024254
Synonyms:
CHEMBL125021
Type:
Small organic molecule
Emp. Form.:
C23H20N2O2
Mol. Mass.:
356.4171
SMILES:
CCOC(=O)c1ccc(cc1)-c1nn(Cc2ccccc2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: